Head of laboratory – Galina V. Seledtsova, PhD, MD, ,
Tel :+7 (383)2224861
Staff of laboratory
1Sergey N. Belogorodtsev PhD, senior researcher.
2. Irina P. Ivanova, PhD,senior researcher, .
3. Ericka A, Kashchenko Eric A., PhD, researcher,
Basic research areas
1. Mechanisms of tumor-associated antigens recognition and development of specific immunological approaches for stimulating anti-tumor autoimmunity. Development of immunotherapeutic drugs on the base of xenogeneic tumor and tissue antigens.
2. Pathogenesis of autoimmune diseases and development of immunologic approaches for ther treatment.-Development and preparation of vaccines based on the autoantigens when antigens are known (rheumatoid arthritis, multiple sclerosis, of allergy). Development and preparation of vaccines in cases of polyantigenic diseases (lupus erythematosus, Crohn's disease, asthma, etc.).
3. Mechanisms of tissue regeneration and approaches to stimulate the regeneration in various organs, development of cellular technologies to stimulate regeneration of:.
- kidney diseases
brain and spinal cord diseases and trauma
- bone and articular diseases.
Dissertations accomplished in the laboratory
Galina V. Seledtsova. Immunoregulatory and anti-tumor properties of nuclear erythroid cells. 2003.
Irina P Ivanova. Regulatory and effector functions of peripheral blood neutrophils in patients with hay fever. 1993.
Sergey A. Savchenko. Reconstructive surgery of the spinal cord in its traumatic injury (experimentally and clinical study). 2005.
Olga V. Poveshchenko. Cytostatic activity of low molecular weight products of tumor cells. 2005.
Maria A. Surovtsev Clinical and immunological study of the effectiveness of cell vaccine for melanoma of the skin. 2006.
Yuri A. Kozhevnikov. Experimental rationality of cellular technology application in the treatment of liver cirrhosis and acute liver failure (experimental study), 2006.
Sergey N. Belogorodtsev. The use of autologous bone marrow stromal cells in the treatment of articular cartilage defects (experimental study), 2006.
Aleksey Y. Velichko. Fetal stem cells in treatment of patients with liver cirrhosis. 2006.
Erika A. Kashchenko Study the effectiveness of specific and nonspecific immunotherapy of melanoma in mice. 2009
Aleksey A. Shishkov. Clinical and immunological study of the efficacy of vaccine therapy in malignant tumors of the colon. 2013.
Publications:
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Kozlov V.A., Chernykh E.R., Starostina N.M., Kozhevnikov V.S., Seledtsova G.V., Sennikov S.V., Ostanin A.A. Cellular technologies in medicine // Technopolis XXI.- 2009.- N 1 (17).- P. 1-17.
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Sadovskaya VA, Sennikov SV, Ostanin AA, Seledtsova GV, Silkov AN, Kozlov VA. Ontogenetic features of the expression of mRNA isoforms for leukemia-inhibitory factor in human fetal tissues and mononuclear cells. // Bull Exp Biol Med. 2009; 147(4), pp.521-524.
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P. Ivanova, V. I. Seledtsov, G. V. Seledtsova, S. V. Mamaev, A. V. Potyemkin, D. V. Seledtsov, and V. A. Kozlov. Induction of Antiidiotypic Immune Response with Autologous T-cell vaccine in Patients with Multiple Sclerosis. // Bull Exp Biol Med. 2008; 146(1), p.133.PDF
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Seledtsova G.V., Rabinovich S.S., Belogorodtsev S.N., Parlyuk O.V., Seledtsov V.I., Kozlov V.A. Delayed Results of Transplantation of Fetal Neurogenic Tissue in Patients with Consequences of Spinal Cord Trauma // Bulletin of Experimental Biology and Medicine. 2010 – Vol.149. – N4. – P. 530-533.PDF
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V.I. Seledtsov, A.A. Shishkov, G.V. Seledtsova .Xenovaccinotherapy for Cancer. Current Cancer Treatment – Novel Beyond Conventional Approaches( 2011) - 415-428PDF
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Seledtsov VI, Seledtsova GV. A balance between tissue-destructive and tissue-protective immunities: a role of toll-like receptors in regulation of adaptive immunity.// Immunobiology. 2012 Apr;217(4):430-5.
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Irina Ivanova , Galina Seledtsova, Sergey Mamaev , Alexey Shishkov , Viktor Seledtsov. Immune responses induced by T-cell vaccination in patients with rheumatoid arthritis.// Human Vaccines &Immunotherapeutics. 2014, v.10. n5. 1221-1227PDF
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Seledtsov V.I., Goncharov A.G., Seledtsova G.V. Clinically feasible approaches to potentiating cancer cell-based immunotherapies// Human vaccines &immunotherapeutics. 2015.: 11; 4, 1-19 doi: 10.1080/21645515.2015.1009814 PDF
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Seledtsov V.I., Goncharov A.G., Seledtsova G.V. Multipurpose immunotherapy for cancer.// Biomedicine and pharmacotherapy. 2015 (76) ,24-29 doi:10.1016/j.biopha.2015.10.0 PDF
Patents for inventions
- Efremov AV, Ivochkin AM, Rabinovich SS, Seledtsov VI, Taraban VJ. A method for treatment of traumatic coma / RU, invention patent number 2160113, December 10, 2000
- Seledtsov VI, Samarin DM, Seledtsova GV Senyukov VV, Strunkin DN, Kozlov VA. Method of cancer vaccine therapy / RU, invention patent number 2192883, November 20, 2002
- Seledtsov VI, Samarin DM, Seledtsova GV, Senyukov VV, Strunkin DN, Kozlov VA. A vaccine for stimulating of antitumor immunity / RU, invention patent number 2192884, November 20, 2002
- Kozlov.V.A., Tsyrlova IG, Seledtsov VI, Seledtsova GV, Samarin DM, Senyukov VV, Akimenko ZA. Cytotoxic factor of natural origin and method of their obtaining / RU, invention patent number 2233663, July 9, 2002
- Rabinovich SS, Kozlov VA, Kolosov NG, Ivochkin AM A method for treatment of traumatic spinal cord injury / RU, invention patent number 2195941, January 10, 2003
- Rabinovich SS, Seledtsov VI. Facility for the treatment of cerebral palsy / RU invention patent number 2233665, August 10, 2004
- Rabinovich SS, Seledtsov VI, Samarin DM, Savchenko SA. Facility for treatment of injury of spinal cord and brain / RU invention patent number 2290939, January 10, 2007
- Belogorodtsev SN Samarin DM, Seledtsov VI, Kolosov NG Method for the treatment of articular surface defects / RU invention patent number 2319456 of March 20, 2008
- Akhmetzhan AD, Belogorodtsev SN, Seledtsova GV, Kolosov NG, Rybin V.V., Shivtsova OA. Method of treating chronic osteomyelitis with a bone defect / RU, an invention patent number 2389442 on May 20, 2010