Laboratory Staff:
Orlovskaya Irina Anatolyevna, MD, PhD – head of the laboratory
Toporkova Lyudmila Borisovna, PhD – senior research assistant
Research
Molecular mechanisms of hematopoietic stem cells and progenitors functional activity in healthy organism and in immune disorders. Search for new targets and approaches for correction of hematopoietic stem cell behavior in immunopathologic conditions and during hematopoietic stem cell transplantation.
Selected publications in English from 2003
1. Naira Serobian, Irina Orlovskaya, Vladimir Kozlov, Sophia Khaldoyanidi. Exposure to nicotin during gestation interferes with the colonization of fetal bone marrow by hematopoietic stem/progenitor cells // Stem Cells and Development, 2005, vol. 14, p. 81-91.
2. Andryushkova A.A., Kuznetsova I.A., Orlovskaya I.A., Buneva V.N., Nevinsky G.A. Antibodies with amylase activity from the sera of autoimmune-prone MRL/MpJ-lpr mice // FEBS Lett., 2006, vol. 580 (21), p. 5089-5095.
3. Naira Serobian, Suchitra Jagannathan, Irina Orlovskaya, Ingrid Schraufstatter, Marina Skok, Jeanne Loring, Sophia Khaldoyanidi. The cholinergic system is involved in regulation of the development of the hematopoietic system // Life Sciences, 2007, vol. 80, p. 2352-2360.
4. Alexandra A Andryushkova , Irina A Kuznetsova , Valentina N Bineva , Ludmila B Toporkova , Ludmila V Sakhno , Marina A Tikhonova , Elena R Chernykh , Irina A Orlovskaya , Georgy A Nevinskyю Formation of different abzymes in autoimmune-prone MRL-lpr/lpr mice is associated with changes in colony formation of haematopoietic progenitors // J. Cell. Mol. Med., 2007, vol. 11(3), p. 531-51
5. Irina A. Kuznetsova, Irina A. Orlovskaya, Valentina N. Buneva, Georgy A. Nevinsky. Activation of DNA-Hydrolyzing antibodies from the sera of autoimmune-prone MRL-lpr/lpr mice by different metal ions.// Biochemica et Biophysica Acta, 2007, vol. 1774, p. 884-896.
6. Irina Orlovskaya, Ingrid Schraufstatter, Jeanne Loring, Sophia Khaldoyanidi. Hematopoietic differentiation of embryonic stem cells. Methods, 2008, v 45, p. 169-167.
7. Nadezhda Omelyanchuk, Irina A. Orlovskaya, Ingrid U. Schraufstatter and Sophia K. Khaldoyanidi. Key Players in the Gene Networks Guiding ESCs toward Mesoderm. Journal of Stem Cells. 2009. V. 4, issue 3, P. 147-160.
8. Andryushkova AA ,Kuznetsova IA,Orlovskaya IA,Buneva VN, Nevinsky GA. Nucleotide-hydrolyzing antibodies from the sera of autoimmune-prone MRL-lpr/lpr mice. Int Immunol.2009;21(8):935-45. 2009.
9. Ingrid Schraufstatter1, Naira Serobyan, Richard DiScipio, Natalia Feofanova, Irina Orlovskaya and Sophia Khaldoyanidi1. Hyaluronan Stimulates Mobilization of Mature Hematopoietic Cells but Not Hematopoietic Progenitors. J. of Stem Cells – 2010. – V. 4. - Issue 4. – Р.191-202.
10. Kostrikina IA, Kolesova ME, Orlovskaya IA, Buneva VN, Nevinsky GA. Diversity of DNA-hydrolyzing antibodies from the sera of autoimmune-prone MRL/MpJ-lpr mice. J Mol Recognit. 2011 – т. 24, № 4 – С. 557-69.
11. I.A. Orlovskaya, S. K. Khaldoyanidi. Critical analysis of methods used for hematopoietic differentiation of embryonic stem cells. Biology Bulletin Reviews. V. 1, 6 (2011), 509-516.
12. Gileva IP, Viazovaia EA, Toporkova LB, Tsyrendorzhiev DD, Shchelkunov SN, Orlovskaya IA. TNF binding protein of variola virus acts as a TNF antagonist at epicutaneous application. Curr Pharm Biotechnol. 2015;16(1):72-6.
13. Doronin VB, Parkhomenko TA, Korablev A, Toporkova LB, Lopatnikova JA, Alshevskaja AA, Sennikov SV, Buneva VN, Budde T, Meuth SG, Orlovskaya IA, Popova NA, Nevinsky GA. Changes in different parameters, lymphocyte proliferation and hematopoietic progenitor colony formation in EAE mice treated with myelin oligodendrocyte glycoprotein. J Cell Mol Med. 2015 Oct 23. doi: 10.1111/jcmm.12704.
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