Laboratory staff:
Gaidul Konstantin V., Doctor of Medical Sciences, Professor - Head of the Laboratory
Chepurnov Alexander. A., Doctor of Biological Sciences, Professor - Leading researcher
Musatov Mikhail I., Doctor of Medical Sciences - Researcher
Goldina Irina A., - Researcher
Lubimov Gennady Yu., PhD - Researcher
Safronova Irina V., PhD - Researcher
Larionova Alla V. - Assistant researcher
Main research fields
1. Investigation of mechanisms for human endogenous retroviruses in the pathogenesis of multiple sclerosis, rheumatoid arthritis, osteoarthritis.
2. The study of the role of small interfering RNA (siRNA) in the critical moments of the virus-cell interactions.
3. Develop a modified antimicrobial drugs based on the use of nanostructured silica and mechanical methods.
4. Development of epigenome-modulating phytonutrients that have therapeutic potential for the prophylaxis and complex treatment of oncological, cardiovascular, endocrine, autoimmune and neurodegenerative diseases.
Publications (2011-2015)
1. Goldina I.A., Gaidul K.V, Smagin A.A, Safronova I.V., Goldin B.G., Pavlov V.V., Lubarskii M.S., Kozlov V.A. Gene expression of endogenous retroviral envelope of human Class I in blood mononuclear cells of patients with multiple sclerosis // Molecular Medicine. - 2011. - №. 1.- P. 31 - 35.
2. Goldina I.A., Gaidul K.V., Kozlov V.A. Human endogenous retrovirus HERV - E ƛ 4-1 in the pathogenesis of multiple sclerosis: the immunomodulatory properties of the retroviral peptide // Neuroimmunology. - 2011. - V. IX - №. 3 - 4 – P. 55 - 56.
3. Dushkin A.V., Lykov A.P., Larina O.N., Guskov S.A., Evseenko V.I., Goldina I.A., Safronova I.V. , Gaidul K.V., Lyakhov N.Z., Kozlov V.A. Comparative antimicrobial activity of antibiotics cephalosporin group modified by mechanical grinding with sorption on nanostructured silica particles // Fundamental Research. - 2011. - № 9. - P. 234 - 237.
4. Dushkin A.V., Gaidul K.V., Goldina I.A, Guskov S.A., Evseenko V.I., Lyakhov N.Z., Kozlov V.A. The antimicrobial activity of antibiotics mechanical synthesized composites and nanostructured silicon dioxide // Reports of the Academy of Sciences. - 2012. - V. 443.- № 1. - P.120- 122.
5. Dushkin A.V., Lykov A.P., Larina O.N., Guskov S.A., Evseenko V.I., Goldina I.A., Safronova I.V. , Gaidul K.V., Lyakhov N.Z., Kozlov V.A. Comparative characteristics of the antimicrobial activity mechanical modified and adsorbed on nanostructured particles of silica forms of ceftazidime on the example of experimental sepsis in mice // Fundamental Research. - 2012. - № 4 (1). - P. 47-52.
6. Gaidul K.V., Lykov A.P., Larina O.N., Goldina I.A., Safronova I.V., Guskov S.A., Evseenko V.I., Dushkin A.V., Lyakhov N.Z., Kozlov V.A. The therapeutic efficacy of antibiotics mechanical synthesized compositions and nanostructured silica in experimental sepsis in mice (CBA x C57Bl / 6) F1 // Bull. SB RAMS. - 2012. - V. 32. - № 3. - P. 5 - 10.
7. Gaidul K.V., Lykov A.P., Larina O.N., Goldina I.A., Safronova I.V., Guskov S.A., Dushkin A.V., Lyakhov N.Z., Kozlov V.A. Wound healing effect of fosfomycin formulations nanostructured silica obtained mechanical, on the model of cut and burn the skin wounds // Bull. SB RAMS. - 2012. - V. 32. - № 3. – P.11 - 17.
8. Goldina I.A., Gaidul K.V., Kozlov V.A. Induction of gene expression of the endogenous retroviral envelope HERV-E λ 4-1 in immunocompetent cells with a high level of functional activity of the immunological // Rus. J. Immunol. - 2012. - V. 6 (14). - № 3. – P. 63 - 65.
9. Goldina I.A., Gaidul K.V. Immunotropic properties of human endogenous retrovirus HERV - E λ 4 - 1, with the introduction of his lifetime his region ENV protein experimental animals // International Scientific and Research Journal. - 2013. - № 9. - Part 3. - P. 20 - 24.
10. Smagin A.A., Goldina I.A.,, Gaidul K.V., Lubarskii M.S. Study of proliferative activity of mononuclear blood cells of patients with multiple sclerosis when exposed to the peptide region ENV endogenous human retrovirus HERV-E λ 4 - 1 // Medical Immunology. - 2013. - V. 4. - P. 52-59.
11. Lykov A.P., Konenkov V.I., Gaidul K.V., Poveshchenko O.V., Goldina,I.A., Dushkin A.V., Kozlov V.A. Antimicrobial activity mechanical immobilized on nanostructured silica particles antibiotics // Biopharm. J. - 2013. - V. 5. - № 1. – P. 13 - 20.
12. Goldina I.A., Mitrofanov I.M., Pavlov V.V., Gaidul K.V. Mechanisms of activation of endogenous retroviruses person: superinfection Chlamydia Trachomatis // Rus. J. Immunol. - 2013. - V. 7 (16). - №2 - 3. - P. 230.
13. Goldina I.A., Gaidul K.V. Mitogen - stimulated expression of endogenous retrovirus HERV-E λ 4-1 in mononuclear blood cells of healthy individuals and patients with multiple sclerosis // Natural Sciences and Humanism. - 2014. - V.8. - N.1. - P. 29-32.
14. Goldina I.A., Pavlov V.V., Mitrofanov I.M., Gaidul K.V. Human endogenous retrovirus HERV-E λ 4-1 expression in coxae arthroplastic // Eur. J. Nat. History, 2014. - N. 1. - P. 10-14
15. Lubimov G. Yu, Goldina I.A., Grishina L.V., Gaidul K.V. Influence of oil extract CURCUMA LONGA L. on the growth of Lewis lung carcinoma in experimental immunological // Russ. J. Immunol. - 2014 – V.8 (17). - №. 3. - P. 702-704.
16. Kuhn J.H., Andersen K.G., Bào Y., Bavari S., Becker S., Bennett R.S., Bergman N.H., Blinkova O., Bradfute S., Brister J.R. , Bukreyev A., Chandran K., Chepurnov A.A. et al. "Filovirus RefSeq Entries: Evaluation and Selection of Filovirus Type Variants, Type Sequences, and Names" // Viruses. - 2014. - N. 6. - P. 3663-3682.
17. Cheresiz S.V., Kononova A.A., Razumova Yu.V., Dubich T.S., Chepurnov A.A., Kushch A.A., Davey R., Pokrovsky A.G. A vesicular stomatitis pseudovirus expressing the surface glycoproteins of in fl uenza A virus. // Arch Virol. - 2014- Jun 3. (DOI 10.1007 / s00705-014-2127-y).
18. Shtanko O., Nikitina R.A., Altuntas C.Z., Chepurnov A.A., Davey R.A. Crimean-Congo Hemorrhagic Fever Virus Entry into Host Cells Occurs through the Multivesicular Body and Requires ESCRT Regulators. // PLoS Pathog. - 2014. - V.10. - N. 9. - e1004390.
19. Musatov M.I., Gaidul K.V. Turmeric in the experimental murine melanoma chemotherapy. // Vestnik NGU. - 2014 -V. 3.- №.12.- P.49-52.
20. Goldina I.A., Gaidul K.V. The biological activity and therapeutic properties of Curcuma Longa L. (review) // Vestnik NGU. - 2015. - T.13. - Vol. 1. - P. 141-149.
21. Safronova I.V., Goldina I.A., Gaidul K.V., Kozlov V.A. Biologically active components of cranberries and their application in medicine. // Innovations and Food Security. - 2015. - № 1 (7). - P. 6-18.
22. Goldina I.A., Safronova I.V., Gaidul K.V. Blueberry polyphenolic compounds: characteristics and biological activity of therapeutic properties. // International Journal of Applied and Fundamental Research. - 2015. - № 10 (2). - P. 221 - 228.
23. Goldina I.A., Pavlov V.V., Prokhorenko V.M., Gaidul K.V. The proliferative activity of mononuclear blood cells in patients with coxarthrosis associated with persistent infection Chlamydia Trachomatis // International Journal of Applied and Fundamental Research. - 2015. - №8. - P. 486 - 489.
24. Goldina I.A., Pavlov V.V., Gaidul K.V. Induction of the endogenous retrovirus HERV-E λ 4-1 expression at hip joint endoprosthetic operation // Science XXI century. Proceedings of materials the international scientific conference Czech Republic, Karlovy Vary - Russia, Moscow, 30-31 July 2015. - 2015. - P. 595-604.
25. Goldina I.A, Pavlov V.V., Gaidul K.V. Gene expression of IL-6 in the differential diagnosis of infectious complications in paraproteznyh hip arthroplasty // Medical Immunology. - 2015. - V.17. - № 3. - P. 223.
26. Shelemba A.A., Lushnikova E.L., Kolesnikov S.I., Nepomnyashchikh L.M., Chepurnov A.A. The role of protein vp24 Ebola virus in the inhibition of interferon-2015 // BEBM.-V.160.-№9.-P.335-338.
27. Musatov M.I., Gaidul K.V. General questions of clinical use of turmeric // Vestnik NGU. - 2015 T. 13. - V. 2. - P. 83-91.
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