Laboratory of molecular immunology

History of the organization of laboratory

    The laboratory has been organised by the order of ICI SB RAMS director V.A.Kozlov on April, 9th,2003. By the same order the head of laboratory has been
    appointed GrandPhD S.V.Sennikov.

The basic publications of laboratory employees from 2004 to 2010

1. Yatsenko OP, Filipenko ML, Voronina EN, Khrapov EA, Sennikov SV, Kozlov VA. Alternative splicing of murine interleukin-4 mRNA.//Bull Exp Biol Med. 2004; v.137 (2), pp.179-81. English.

2. Yatsenko OP, Filipenko ML, Khrapov EA, Voronina EN, Sennikov SV, Kozlov VA. Alternative splicing of Interleukin-6 mRNA in mice.//Bull Exp Biol Med. 2004; v.138 (1), pp.73-76 English.

3. Kuramshin D.H., Sennikov S.V., Kozlov V.A. Immunotropical property of causative agent of virus hepatitis С// J Med Embriol and Immonol (ЖМЭиИ), 2004, №2, p. 110-114 Russian.

4. Turchinovich A.A.; Deineko E.V.; Filipenko M.L.; Khrapov E.A.; Zagorskaya A.A.; Filipenko E.A.; Sennikov S.V.; Kozlov V.A.; Shumnyi V.K. Transgenic Tobacco Plants Producing Human Interleukin-18.//Dokl Biochem Biophys., 2004, vol. 395, №. 4, p. 104-107 English.

5. Silkov A.N., V. A., Denisova V.D., Grishina L.V., Sennikov S.V., Kozlov V.A. Effect of rhIL-4δ2 on PBMC in Vitro.//In “Immunology 2004. Cytokine Network, and Regulatory Cells, Signaling, and Apoptosis”, 2004, Medimond, Inernational proceedings, p.367-372 English

6. Denisova V.V., Kulagin A.D., Kruchkova I.V., Sizikova S.A., Lisukov I.A., Sennikov S.V., Kozlov V.A. Postchemotherapy production of negative regulators of hematopoiesis by erythroid marrow nuclear cells in lymphoma patients.//In “Immunology 2004. Cytokine Network, and Regulatory Cells, Signaling, and Apoptosis” 2004, Medimond, Inernational proceedings, p.103-108 English

7. Yakushenko E.V., Lopatnikova J.A., Khrapov E.A, FilipenkoM.L., Pustoshilova N.M., Zakabunin A.I, Sennikov S.V., Kozlov V.A. Biological and specific activity of recombinant human Interleukin-18.//In “Immunology 2004.Cytokine Network, and Regulatory Cells, Signaling, and Apoptosis” 2004, Medimond, Inernational proceedings, p.423-428. English.

8. Herzog O.A., Sennikov S.V., Konenkova L.P., Zonova E.V., Korolev M.A., Sizikov A.E., Kozlov V.A. High inflammatory activity and increase of interferon gamma and interleukin-12 levels in anaemic patients with debut of rheumatoid arthritis.//In “Immunology 2004. Autoimmunity, Genetic and Degenerative disorders” 2004, Medimond, Inernational proceedings, p.75-78 English.

9. Sennikov S.V., Injelevskaya T.V., Krysov S.V., Silkov A.N., Kovinev I.B., Dyachkova N.J., Zenkov A.N., Loseva M.I., Kozlov V.A. Production of hemo- and immunoregulatory cytokines by the erythroblast antigen + and glycophorine A + cells from human bone marrow.//BMC Cell Biol. 2004 Oct 18; 5(1):39 English.

10. «System of cytokines. Theoretical and clinical aspects», Сollected articles, editors: Kozlov V.A. and Sennikov S.V., c.Novosibirsk, the Science, 2004, 323 p. Russian. 11. Sennikov S.V., Silkov A.N., Kozlov V.A. Alternative splicing in forming of polymorphic structure of cytokine systems //In.: «System of cytokines. Theoretical and clinical aspects » 2004, Novosibirsk, the Science, p. 7-23. Russian.

11. Yatsenko O.P., Filipenko M.L., Khrapov E.A., Voronina E.N., Kozlov V.A., Sennikov S.V. Alternative splicing of mRNA of mouse interleukin-4 and interleukin-6.//Cytokine, 2004 Vol. 28, №4-5 pp. 190-196. English.

12. Kovshik I. G., Silkov A. N., Sennikov S V., Shurlygina A V., Trufakin V.A. Proliferative activity of cells in mouse thymus and spleen under different diurnal regimens of interleukin-2 administration.//Bulletin of Experimental Biology and Medicine, 2006, Vol. 142, No. 1, pp. 98-101. English.

13. Khrapov E.A., Lopatnikova J.A., Voronina E.N., Yakushenko E.V., Zakabunin A.I., Sennikov S.V., Pustoshilova N.M., Kozlov V.A., Filipenko M.L. Expression of human interleukin-18 in E.coli and biological activity of recombinant protein. In «Biotechnology in biology and medicine. Editors: A.M. Egorov and G. Zaikov, 2006, Nova Science Publishers, Inc., New York, rr.13-24 English.

14. Yakushenko E.V., Lopatnikova J.A., Khrapov E.A., Deineko E.V., Filipenko M.L., Voronina E.N., Turchinovich A.A., Filipenko E.A., Pukhnatcheva N.A., Tukavin G.B., Schmikova N.A., Shumny V.K., Sennikov S.V., Kozlov V.A. Use of transgenic carrot plants producing human interleukin-18 for modulation of mouse immune response. In «Biotechnology in biology and medicine. Editors: A.M. Egorov and G. Zaikov, 2006, Nova Science Publishers, Inc., New York, rr.97-107 English.

15. Silkov A. N., Gavrilenko V. A., Denisova V. V., Grishina L. V., Kozlov V. A., Sennikov S. V. Effects of recombinant IL-4δ2 on human peripheral blood mononuclears // Bulletin of Experimental Biology and Medicine, 2007, Vol. 143, No. 1, pp.72-74 English.

16. Denisova V. V., Kulagin A. D., Lisukov I. A., Kryuchkova I. V., Sizikova S. A., Sennikov S. V. , Kozlov V. A. Cytokine-producing activity of bone marrow erythrokaryocytes and its regulation under normal conditions // Bulletin of Experimental Biology and Medicine, 2007, Vol. 143, No. 2, p.118-121. English.

17. Shojhet J.N., Kozlov V.A., Trufakin V. A, Konenkov V. I, Koljado I.B., Habarov A.S., Sennikov S.V., Kiselyov V. I, Marchenko T.A., Algazin A.I., Gordeyev V.V., Plugin S.V., Dikarev С.N. Immune status of the population living in areas of ecological trouble, Vol.1. –« The immune status of the population in a zone of influence of nuclear tests » // Barnaul, Alphabet, 2007, 185 p. Russian.

18. Shojhet J.N., Kozlov V.A.,, Trufakin V. A, Koljado I.B., Sennikov S.V., Koljado V. B, Plugin S.V., Baranov O.P., Habarov A.S., Bogdanov S.V., Dikarev S.N. Immune status of the population living in areas of ecological trouble, Vol.2. The immune status of children and fertile women , living in the territories adjoining to areas of falling of separating parts of the second steps of carrier rockets» // Barnaul, the Alphabet, 2007, 143 p. Russian.

19. Turchinovich A.A., Dejneko E.V., Filippenko M. L, Shumnii V.К, Khrapov E.A., Sennikov S.V. Recombinant plasmid DNA pBi101-IL18, coding synthesis of IL-18 in transgenic plants // patent for invention №2302460 from 10.07.2007.

20. Vedina L. A., Sennikov S V., V. A., V. A. Restoration of Hemopoiesis and Immunopoiesis with Small Intestinal Epitheliocytes in Lethally Irradiated Mice.//Bulletin of Experimental Biology and Medicine, 2007, Vol. 143, № 4, p.524-527. English.

21. Shevchenko IuA, Iakushenko EV, Sennikov SV, Laushkina ZhA. Modulation of an antituberculous immune response in vitro, by using antigen-activated dendritic cells. Probl Tuberk Bolezn Legk. 2008;(2):33-5. Russian.

22. Vedina LA, Sennikov SV, Trufakin VA, Kozlov VA. Stem cells of small intestinal epithelium.// Bull Exp Biol Med. 2008 Apr;145(4):495-8. Review. English.

23. Yakushenko Е.V., Lopatnikova J.А.,. Sennikov S.V, Shatalina М.N., Deinekо Е.V., Voroninа Е.N.,. Khrapov Е.А, Filipenko M.L., Shumny V.K., Kozlov V.A. Using of Transgenic Carrot Plants Producing Human Interleukin-18 for studu of Mouse Immune Response Modulation..// Bul SB RAMS2008. №3(131), р. 70-75. Russian.

24. Khripko O.P., Sennikova N.S., Lopatnikova J.A., Khripko J.I., Filipenko M.L., Khrapov E.A., Gelfgat E.L., Yakushenko E.V., Kozlov V.A., Sennikov S.V. Association of Single Nucleotide Polymorphisms in the IL-18 Gene with Production of IL-18 Protein by Mononuclear Cells from Healthy Donors // Mediators of Inflammation. 2008;2008:309721. Epub 2008 Oct 20. 6 pages. English

25. Khripko O.P, Yakushenko E.V., Sennikov S.V., Kozlov V.A., Krasilnikova I.V. Used Dendritic Cell and Interleukin-18 for Modulation of Immune Response against HBcAg in vitro// Bul SB RAMS 2008, № 5 (133), р.109-113 Russian.

26. Sadovskaya VA, Sennikov SV, Ostanin AA, Seledtsova GV, Silkov AN, Kozlov VA. Ontogenetic features of the expression of mRNA isoforms for leukemia-inhibitory factor in human fetal tissues and mononuclear cells.// Bull Exp Biol Med. 2009 Apr;147(4):521-4. English, Russian.

27. Silkov A.N., Goreva Е.P., Jovmer А.S., Kireev F.D., Maksimov V.N., . Pilipenko I.V, Мalinovskay Е.А., Babishkina N.N., Litvyakov N.V. Sennikov S.V.,Коzlov V.А. Polymorphism genes IL-18 and IL-1β in Patients with Breast Cancer.// Russ J Immunol. 2009, 3(12), № 3–4 р.259-266/ Russian.  

28. Sadovskaya VA, Sennikov SV, Seledtsova GV, Silkov AN, Kozlov VA. Evaluation of the expression of isoforms of stem cell factor mRNA in fetal tissues and mononuclear cells at different stages of human development.// Bull Exp Biol Med. 2010 Dec;150(1):122-4.

29. Autenshlyus A.I., Sosnina A.V., Poddubnaya L.V., Ziryanova T.V., Lopatnikova Yu.A., Sennikov S.V. Classes and subclasses of autoantibodies to TNF-α in pulmonary tuberculosis patients. Tuberk and Bolezn Legk., 2010.-N 11.-p.57-60. Russian.

The dissertational works executed on the basis of laboratory from 2004 to 2010 </em>

    1. Grishina L.V.« Prevalence of immunopathological syndromes and characteristic of immune system at persons, underwent influence of small doses of radiation». The dissertation on competition of a scientific degree of a Candidate of Biological Science. 2004. The scientific adviser was the S.V.Sennikov
    2. Denisov V.V.« Morphofunctional characteristic of erythroid marrow nuclear cells in lymphoma patients on application of chemotherapy ». The dissertation on competition of a scientific degree of a Candidate of Medical Science. 2004. The scientific adviser was the academician of RAMS Kozlov V.A.
    3. Silkov A.N.« Expression of splajs-variants mRNA of IL-4 gene in mononuclear and erithroid cells and functional characteristic of recombinant IL-4 delta2» The dissertation on competition of a scientific degree of a Candidate of Biological Science. 2004. The scientific adviser was the S.V.Sennikov
    4. Herzog O.A. « Clinicoimmunologic characteristic patients with rheumatoid arthritis at various allelic variants of genes TNF-alpha (-308) and IL-1-beta (+395) ». The dissertation on competition of a scientific degree of a Candidate of Medical Science. 2006. The scientific adviser was the academician of RAMS Kozlov V.A.
    5. Lopatnikova J.A.«Biological properties of recombinant protein IL-18, IL-18BP and transgenic plant Daucus Carota L., carrying the gene of IL-18 » The dissertation on competition of a scientific degree of a Candidate of Biological Science. 2006. The scientific adviser was the S.V.Sennikov
    6. Vedina L.A. « Restoration of Hemopoiesis and Immunopoiesis with Small Intestinal Epitheliocytes in Lethally Irradiated Mice», The dissertation on competition of a scientific degree of a Candidate of Biological Science. 2006. The scientific adviser was S.V.Sennikov

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    Phone: +7(383) 222-78-08, +7(383) 222-19-10, Fax: +7(383) 2227028,

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